Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.6
USERS' SCORE
Good
Based on 6 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9.5
We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.
Read More
8
We investigated how systemic hyaluronic acid could aid in treating arthritis, particularly through intravenous use. This approach offers a viable alternative to traditional injections, especially for difficult-to-reach joints.
In our study with an arthritis mouse model, we found that hyaluronic acid gathered in inflamed joints, leading to noticeable reductions in swelling, redness, and other inflammatory markers. Despite these positive observations, it's important to note that overall results did not indicate a significant improvement in arthritis outcomes.
Nevertheless, our findings support further exploration of systemic hyaluronic acid as a potential treatment strategy.
In our study with an arthritis mouse model, we found that hyaluronic acid gathered in inflamed joints, leading to noticeable reductions in swelling, redness, and other inflammatory markers. Despite these positive observations, it's important to note that overall results did not indicate a significant improvement in arthritis outcomes.
Nevertheless, our findings support further exploration of systemic hyaluronic acid as a potential treatment strategy.
Read More
9
We explored a novel approach to treat rheumatoid arthritis using hyaluronic-acid-coated transethosomes loaded with tofacitinib. This method focuses on direct delivery to inflamed tissue, potentially reducing systemic side effects often seen with oral tofacitinib.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Read More
Most Useful Reviews
10
Prescription-Free Relief
14 people found this helpful
A few years ago, I was diagnosed with Rheumatoid Arthritis and prescribed medications. However, after a friend's recommendation, I started taking Hyaluronic Acid. Since then, I’ve stopped taking my prescription drugs! I can hardly believe the difference it has made to how I feel. I absolutely love it and can't thank you enough!
Read More
6
Pain Reduction
4 people found this helpful
My mum suffers from rheumatoid arthritis. She takes one capsule twice daily with her meals. This supplement has helped alleviate her pain significantly. Thanks to it, she was able to stop using a painkiller that she had relied on for a year. I definitely recommend it.
Read More
8
Soft Skin, Strong Joints
I have always taken this supplement because it effectively alleviates pain from Rheumatoid arthritis. It also improves my skin's dryness, making it softer, which I believe benefits my joints and connective tissue affected by the condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.6
- All Researches
9.5
We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.
Read More
9
Novel RA treatment strategy explored
This study explored the potential of a new hyaluronic acid-modified nanocatalyst designed to treat rheumatoid arthritis (RA). The research aimed to manipulate immune cells in the body, specifically altering macrophage polarization and combating oxidative stress.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
Read More
9
We explored a novel approach to treat rheumatoid arthritis using hyaluronic-acid-coated transethosomes loaded with tofacitinib. This method focuses on direct delivery to inflamed tissue, potentially reducing systemic side effects often seen with oral tofacitinib.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Read More
9
Promising dual drug delivery strategy
We investigated a novel treatment for rheumatoid arthritis using hyalurosomes that combined dexamethasone and luteolin. This method showed promising results in reducing inflammation and joint swelling in a rat model.
Notably, histological evaluations revealed improvements in key inflammatory markers and overall joint health. However, while the findings are positive, it’s essential to recognize that these results stem from animal studies and may not directly translate to humans.
Notably, histological evaluations revealed improvements in key inflammatory markers and overall joint health. However, while the findings are positive, it’s essential to recognize that these results stem from animal studies and may not directly translate to humans.
Read More
9
We explored a new way to enhance rheumatoid arthritis treatment by developing a slow-release drug delivery system using hyaluronic acid microsponge (MSP) for methotrexate (MTX).
In preclinical studies, MSP maintained a controlled release of MTX, leading to nearly double the therapeutic effectiveness compared to traditional methods.
This innovative approach not only improved treatment outcomes but also aimed to reduce the adverse side effects usually linked with quick-release medications.
The findings suggest that this method could significantly benefit those suffering from rheumatoid arthritis.
In preclinical studies, MSP maintained a controlled release of MTX, leading to nearly double the therapeutic effectiveness compared to traditional methods.
This innovative approach not only improved treatment outcomes but also aimed to reduce the adverse side effects usually linked with quick-release medications.
The findings suggest that this method could significantly benefit those suffering from rheumatoid arthritis.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Prescription-Free Relief
14 people found this helpful
A few years ago, I was diagnosed with Rheumatoid Arthritis and prescribed medications. However, after a friend's recommendation, I started taking Hyaluronic Acid. Since then, I’ve stopped taking my prescription drugs! I can hardly believe the difference it has made to how I feel. I absolutely love it and can't thank you enough!
Read More
6
Pain Reduction
4 people found this helpful
My mum suffers from rheumatoid arthritis. She takes one capsule twice daily with her meals. This supplement has helped alleviate her pain significantly. Thanks to it, she was able to stop using a painkiller that she had relied on for a year. I definitely recommend it.
Read More
8
Soft Skin, Strong Joints
I have always taken this supplement because it effectively alleviates pain from Rheumatoid arthritis. It also improves my skin's dryness, making it softer, which I believe benefits my joints and connective tissue affected by the condition.
Read More
7.5
Easier Autumn Experience
Hyaluronic acid was ordered for my grandmother, who suffers from rheumatoid arthritis and constant pain. She takes it alongside chondroitin. After a month, she mentioned it was much easier for her, and there was no autumn flare-up.
Read More
7.5
Joint Pain Relief
This supplement helps my husband with rheumatoid arthritis, as it noticeably reduces his joint pain.
Read More
Frequently Asked Questions
7.5
Easier Autumn Experience
Hyaluronic acid was ordered for my grandmother, who suffers from rheumatoid arthritis and constant pain. She takes it alongside chondroitin. After a month, she mentioned it was much easier for her, and there was no autumn flare-up.
6
Pain Reduction
4 people found this helpful
My mum suffers from rheumatoid arthritis. She takes one capsule twice daily with her meals. This supplement has helped alleviate her pain significantly. Thanks to it, she was able to stop using a painkiller that she had relied on for a year. I definitely recommend it.
10
Prescription-Free Relief
14 people found this helpful
A few years ago, I was diagnosed with Rheumatoid Arthritis and prescribed medications. However, after a friend's recommendation, I started taking Hyaluronic Acid. Since then, I’ve stopped taking my prescription drugs! I can hardly believe the difference it has made to how I feel. I absolutely love it and can't thank you enough!
8
Soft Skin, Strong Joints
I have always taken this supplement because it effectively alleviates pain from Rheumatoid arthritis. It also improves my skin's dryness, making it softer, which I believe benefits my joints and connective tissue affected by the condition.
9
Novel RA treatment strategy explored
This study explored the potential of a new hyaluronic acid-modified nanocatalyst designed to treat rheumatoid arthritis (RA). The research aimed to manipulate immune cells in the body, specifically altering macrophage polarization and combating oxidative stress.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
9.5
We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.
9
We explored a new way to enhance rheumatoid arthritis treatment by developing a slow-release drug delivery system using hyaluronic acid microsponge (MSP) for methotrexate (MTX).
In preclinical studies, MSP maintained a controlled release of MTX, leading to nearly double the therapeutic effectiveness compared to traditional methods.
This innovative approach not only improved treatment outcomes but also aimed to reduce the adverse side effects usually linked with quick-release medications.
The findings suggest that this method could significantly benefit those suffering from rheumatoid arthritis.
In preclinical studies, MSP maintained a controlled release of MTX, leading to nearly double the therapeutic effectiveness compared to traditional methods.
This innovative approach not only improved treatment outcomes but also aimed to reduce the adverse side effects usually linked with quick-release medications.
The findings suggest that this method could significantly benefit those suffering from rheumatoid arthritis.
9
We explored a new treatment for rheumatoid arthritis (RA) using hyaluronic acid-coated nanogels to deliver tacrolimus directly to inflamed joints. This innovative approach is designed to reduce the side effects commonly seen with traditional therapies. In our study, these nanogels showed improved targeting, leading to a notable decrease in inflammation and joint damage in animal models. The results suggest this targeted delivery system could enhance the efficacy of RA treatment while minimizing toxicity. Overall, this therapy holds promise for safer clinical applications in the future.
References
- Zhang L, Wu G, Yao J, Wang D, Gao F, et al. Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis. Int J Biol Macromol. 2025;309:143143. doi:10.1016/j.ijbiomac.2025.143143
- Liu L, Ma X, Jia X, Hui JH, Hui M. Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. Clin Case Rep. 2025;13:e70361. doi:10.1002/ccr3.70361
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. doi:10.1038/s41467-025-58059-z
- Šimek M, Rubanová D, Nešporová K, Skoroplyas S, Lehká K, et al. Pharmacokinetics of the systemic application of hyaluronic acid for joint arthritis treatment. Int J Biol Macromol. 2025;307:141937. doi:10.1016/j.ijbiomac.2025.141937
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. doi:10.1016/j.colsurfb.2025.114497
- Fiaschini N, Hanieh PN, Ariaudo D, Cimino R, Abbate C, et al. Application of Microsponge Drug Platform to Enhance Methotrexate Administration in Rheumatoid Arthritis Therapy. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16121593
- Elshabrawy HA, Abo Dena AS, Sobhy MH, El-Sherbiny IM. Integrating 3D-printed hydrogels and polymeric nanofibers in a double-layered transdermal patch for the treatment of rheumatoid arthritis. RSC Adv. 2024;14:40187. doi:10.1039/d4ra07306a
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiO₂ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. doi:10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. doi:10.1186/s12951-024-02784-y
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. doi:10.1016/j.ijpharm.2024.124449
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. doi:10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. doi:10.1021/acs.biomac.4c00556
- Wang Y, Wang J, Ma M, Gao R, Wu Y, et al. Hyaluronic-Acid-Nanomedicine Hydrogel for Enhanced Treatment of Rheumatoid Arthritis by Mediating Macrophage-Synovial Fibroblast Cross-Talk. Biomater Res. 2024;28:0046. doi:10.34133/bmr.0046
